A strain of marine actinomycetes with inhibiting tumor cytotoxin activities <i>in vitro</i> isolated from the Taiwan Strait

HUANG Yao-jian; ZHENG Zhong-hui; ZENG Wei; LI Jun; LI Li-jun; SU Wen-jin

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Article Navigation > Haiyang Xuebao > 2001 > 23(6): 128-132

HUANG Yao-jian, ZHENG Zhong-hui, ZENG Wei, LI Jun, LI Li-jun, SU Wen-jin. A strain of marine actinomycetes with inhibiting tumor cytotoxin activities in vitro isolated from the Taiwan Strait[J]. Haiyang Xuebao, 2001, 23(6): 128-132.

Citation:

HUANG Yao-jian, ZHENG Zhong-hui, ZENG Wei, LI Jun, LI Li-jun, SU Wen-jin. A strain of marine actinomycetes with inhibiting tumor cytotoxin activities in vitro isolated from the Taiwan Strait[J]. Haiyang Xuebao, 2001, 23(6): 128-132.

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A strain of marine actinomycetes with inhibiting tumor cytotoxin activities in vitro isolated from the Taiwan Strait

1.
Department of Biology and Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China
2.
Institute of Fishery Biotechnology, Jimei University, Xiamen 361021, China
3.
Department of Biology and Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen University, Xiamen 361005, China;Institute of Fishery Biotechnology, Jimei University, Xiamen 361021, China

Received Date: 2000-02-24
Rev Recd Date: 2000-06-19

Abstract

Abstract

The result of study on inhibiting tumor activities and identification of a strain of marine Strepto myces,N350 is reported,which is isolated from a species of sea plants,Gracilaria sp.,collected from the Taiwan Strait.Inhibiting tumor activity is studied with MTT assay in vitro and DNA-target activity is studied with BIA spot test.Their effect on the growth of eight cancer cell lines and the ID₅₀ dilutions for the broth against cancer cells ranges from 1:2 560 to greater than 1:20 480.The BIA test shows also the culture displayed inducing activity.The BIA activity of the artificial sea water cultures is 16.4 times higher than tap water.The strain is identified as Streptomyces tauricus var.marinus.
- Streptomyces,
- Streptomyces tauricus,
- inhibiting tumor activities

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References(11)

References

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