Screening of marine actinomycetes producing polysaccharides with immunomodulating activity

SU Wen-jin; HUANG Yi-li; HUANG Yao-jian; ZHENG Zhong-hui; SONG Si-yang; CHEN Jin-an

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Article Navigation > Haiyang Xuebao > 2001 > 23(6): 114-119

SU Wen-jin, HUANG Yi-li, HUANG Yao-jian, ZHENG Zhong-hui, SONG Si-yang, CHEN Jin-an. Screening of marine actinomycetes producing polysaccharides with immunomodulating activity[J]. Haiyang Xuebao, 2001, 23(6): 114-119.

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Screening of marine actinomycetes producing polysaccharides with immunomodulating activity

1.
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering and School of Life Sciences, Xiamen University, Xiamen 361005, China;Institute of Fishery Biotechnology, Jimei University, Xiamen 361021, China
2.
Key Laboratory of Ministry of Education for Cell Biology and Tumor Cell Engineering and School of Life Sciences, Xiamen University, Xiamen 361005, China

Received Date: 2000-05-15
Rev Recd Date: 2000-08-07

Abstract

Abstract

The purpose of this work is to investigate the production of the extracellular polysacchar ides(EPS) with immunomodulating activity from marine actinomycetes.996 strains of marine actinomycetes are isolated from intertidal zone of Xiamen Island,and 3.3% of themy ield EPS more than 3g/dm³ when determined by method of phenol sulfuric acid.Among the strains with high yield of EPS,there are 3 strains those produe the EPS having immunomodulating activity in vitro by promoting the proliferation and accumulation of interleukin 2(IL-2) of lymphocytes of mouse spleen and in vivo in the animal model.The EP Sproduced by Strain 2305,Streptomyces sp.,is the most promising candidate to develop into immunomodulator in view of its obvious effects on the non specific,cellular and humoral immunity.The results show that the EPS from marine actinomy cetes can be an important resource for the development of immunomodulators.
- extracellular polysaccharides(EPS),
- immunomodulator,
- marine actinomycetes

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References(12)

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