Abstract: In order to improve seismic events’pickup precision, based on many of auto pickup methods, the author selects energy ratio and cross-correlation, and discusses their formula in detail. Testing with the actual data, author analyses their advantage and shortcoming each other, and take medium and average filtering to remove the spike and swell noise for the auto pickup result. To initialize the auto pickup value, the reference seed points are very important, and to pick these important reference seed points, user-computer interactive picking is necessary. In addition, the complex reflecting layers must be picked by the user-computer interactive picking. So user-computer interactive picking is also very important. In practice, auto pickup and user-computer interactive picking must be used simultaneously, and tested with actual data the pickup result is very good by using the above comprehensive methods.